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There are obvious differences between Hodgkin's disease and other malignant neoplasms. Perhaps most striking are the derangement of the immunologic system and the preponderance of the normal-appearing reactive patient's cells (lymphocytes, histiocytes, and eosinophils) with relatively few neoplastic-appearing reticulum cells and Sternberg-Reed cells in Hodgkin's disease. In contrast, other malignant neoplasms have greater numbers of the neoplastic cells and few, if any, reactive cells. Further, the association of an improved prognosis with lymphocyte predominance in Hodgkin's disease and the poorer prognosis when lymphocytes are depleted suggested that immunity played an active and important role in the disease. These features suggested an investigation of possible associated antigens in Hodgkin's disease.
In our studies, we have utilized the unique opportunity provided by staging, laparotomy, and splenectomy to obtain Hodgkin's nodules from splenic and nodal tissue that has not been modified by irradiation or chemotherapy. These tissues are used to immunize rabbits. The
Order SE, Hellman S. Tumor-Associated AntigensA New Perspective of Hodgkin's Disease. JAMA. 1973;223(2):174–175. doi:10.1001/jama.1973.03220020040013