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June 28, 1976

Benign Hemoglobinuria Following Transfusion of Accidentally Frozen Blood

Author Affiliations

From the Blood Bank (Dr Sandler), and the departments of medicine A (Dr Berry) and B (Prof Zlotnick), Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel.

JAMA. 1976;235(26):2850-2851. doi:10.1001/jama.1976.03260520044024

A patient was transfused with a unit of red blood cells that had been frozen accidentally prior to transfusion. Although he had received approximately 60 gm of free hemoglobin intravenously, the patient's only clinical reaction was massive hemoglobinuria. The benign clinical response, in the presence of massive hemoglobinuria, is attributed to the absence of immunologic incompatibility and, thus, failure to activate vasoactive mediators and disseminated intravascular coagulation. The case illustrates revised concepts of the pathophysiology of acute renal failure associated with hemolytic blood transfusion reactions.

(JAMA 235:2850-2851, 1976)