A computer-based approach for instruction and diagnosis of clinical acidbase disorders has been developed. Its significant features are the following: (1) consideration of a differential diagnosis list (rather than a single diagnosis) for any given blood pH plus either carbon dioxide content, bicarbonate level, or partial pressure of carbon dioxide; (2) use of ancillary clinical and laboratory information about the patient to arrive at the most likely diagnosis from the differential diagnosis list; (3) adaptability to users of widely differing clinical expertise and educational backgrounds; and (4) provision for tabulating the relative frequencies of acid-base disorders presented to the computer. The computer's differential diagnosis is based on an acid-base map. A sample case illustrates the logical process involved. This program demonstrates that the computer can mimic the clinical consultant in its approach to diagnosis and in its ability to teach.
Goldberg M, Green SB, Moss ML, Marbach CB, Garfinkel D. Computer-Based Instruction and Diagnosis of Acid-Base DisordersA Systematic Approach. JAMA. 1973;223(3):269-275. doi:10.1001/jama.1973.03220030013003