Ethacrynic acid, a potent diuretic for oral or intravenous use, has a rapid onset and relatively short duration of action. While older, less potent diuretics are preferred for general use, ethacrynic acid may be lifesaving in patients with resistant edemas. Most of the adverse effects (eg, metabolic alkalosis, depletion of chloride and potassium ions) of ethacrynic acid are related to its pharmacological actions. The dosage should be individualized to avoid electrolyte imbalance and dehydration.
Evaluation of a New Oral Diuretic AgentEthacrynic Acid and Ethacrynate Sodium (Edecrin and Edecrin Sodium). JAMA. 1969;208(12):2327–2329. doi:10.1001/jama.1969.03160120051012