[Skip to Content]
[Skip to Content Landing]
February 5, 1973

Remission of Felty's Syndrome With Long-Term Testosterone Therapy

Author Affiliations

From the Section of Hematology, Lovelace Clinic (Dr. Wimer), and the University of New Mexico, School of Medicine (Dr. Sloan), Albuquerque, NM.

JAMA. 1973;223(6):671-673. doi:10.1001/jama.1973.03220060045011

Three men with Felty's syndrome were treated with long-term testosterone therapy. Two had a full, and one a partial, correction of the neutropenia and a concomitant abatement of tendency to infection. For the two patients with complete correction of the neutropenia, full recovery of neutrophils took 20 and 24 months, respectively, correlating with diminution in splenomegaly. Testosterone may increase stem cell commitment to granulopoiesis, at the same time diminishing lymphopoiesis. It may also exert a weak lympholytic effect.