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Article
July 7, 1969

Allergy to Local Anesthetics

JAMA. 1969;209(1):113. doi:10.1001/jama.1969.03160140069022

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Abstract

To the Editor:—  Two letters appeared in the March 24 issue (207: 2283, 1969) commenting on our article entitled "Allergy to Local Anesthetics (207:356, 1969). Both letters warned against the skin testing of definitely allergic drugs; in this particular case, local anesthetics. Contrary to what was stated in one of the letters (L. H. Criep), this group of drugs cannot be compared to penicillin since their chemical composition is different and the incidence of allergic reactions is considerably larger with the latter drug. Therefore, while the skin testing to penicillin has been debatable, it was recently proven as relatively safe, as indicated in the 13 cases reported by Rosenblum (J Allerg42:309, 1968).In the other ten patients that we alluded to in our paper, skin tests were done with local anesthetics and their responses assessed by the passive transfer method (Anesth Analg, to be published). As stated priorly,

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