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Article
February 19, 1973

Rapid Estrogen-Induced Hypercalcemia

Author Affiliations

From the Oncology Division, Medical Services, Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston.

JAMA. 1973;223(8):913-914. doi:10.1001/jama.1973.03220080043012
Abstract

Two menopausal patients with metastatic breast cancer and osteolytic bone metastases were treated with diethylstilbestrol in oral doses. In one patient, hypercalcemia developed within 48 hours of treatment with a total dose of 10.0 mg of diethylstilbestrol, and in the second patient hypercalcemia developed within 24 hours of therapy with a single 5.0-mg oral dose.

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