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February 19, 1973

Rapid Estrogen-Induced Hypercalcemia

Author Affiliations

From the Oncology Division, Medical Services, Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston.

JAMA. 1973;223(8):913-914. doi:10.1001/jama.1973.03220080043012

Two menopausal patients with metastatic breast cancer and osteolytic bone metastases were treated with diethylstilbestrol in oral doses. In one patient, hypercalcemia developed within 48 hours of treatment with a total dose of 10.0 mg of diethylstilbestrol, and in the second patient hypercalcemia developed within 24 hours of therapy with a single 5.0-mg oral dose.