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March 5, 1973

Combined TAB Vaccine

Author Affiliations

Berkeley, Calif

JAMA. 1973;223(10):1158. doi:10.1001/jama.1973.03220100052021

To the Editor.—  In a brief discussion of salmonellosis in the MEDICAL NEWS section of The Journal (222:1117, 1972), the following statement is made: "There is no Salmonella vaccine for humans except S typhi, paratyphoid A and B." This statement leaves the erroneous impression that the combined typhoid and paratyphoid (TAB) vaccine is available. At present, typhoid vaccines are no longer combined with paratyphoid A and B. The effectiveness of paratyphoid A vaccine has never been established and field trials have shown that the small amount of paratyphoid B vaccine present in previous TAB vaccines was not effective.1 Consequently, and because paratyphoid A and B antigens are believed to increase the risk of vaccine reaction with typhoid vaccine, these were deleted from formulations of typhoid vaccine in the last few years.In addition to the difficulties with the combined vaccine, the need for protection against paratyphoid A and B