[Skip to Content]
[Skip to Content Landing]
August 16, 1976

Insulin Lipoatrophy

JAMA. 1976;236(7):820-821. doi:10.1001/jama.1976.03270080012009

To the Editor.—  In their article entitled "Amelioration of Insulin Lipoatrophy by Dexamethasone Injection" (235:839, 1976), Whitley and associates reported a case of insulininduced lipoatrophy. They demonstrated a significant improvement in the lipoatrophy with direct injection of a mixture of dexamethasone and insulin zinc suspension into the depressed area.An obvious control that is lacking in their "experiment" is the injection of insulin alone directly into the lesion. It has now been fairly well established that this injection of singlepeak insuling into areas of lipoatrophy will produce amelioration of the lipoatrophy. The precise pathogenesis of the lipoatrophy or the reason for its remission with direct injection of single-peak insulin remains unknown. This phenomenon is well established, however, and is certainly much simpler for both patient and physician than mixing dexamethasone with insulin. Inasmuch as Dr Whitley and his associates used 100 units of insulin that is single peak, it is