August 4, 1969


JAMA. 1969;209(5):631-640. doi:10.1001/jama.1969.03160180005003

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Which Tumors Are Estrogen-Sensitive  ?

Team Closes In On Answer  A simplified method of determining estrogen-sensitive tumors is being developed by a team of investigators from the University of Washington, Seattle.If the technique proves to be a reliable measure of estrogen-dependent hypertrophy, it could be used to predict which breast cancer patients would respond favorably to oophorectomy, explained Martin Farber, MD, senior research fellow at the university's school of medicine.At present, about two-thirds of these patients do not benefit from removal of their ovaries, but there is no reliable way of predicting clinical response.The technique, described at the fifty-first annual meeting of the Endocrine Society, might also be used to confirm the estrogen sensitivity of uterine cancer. In vitro testing of agents that inhibit estrogen binding and tumor growth might then be feasible.Estrogen binding to receptor proteins in the myometrium is thought to be a very