Galactorrhea occurred after use of oral contraceptives in three sisters with oligo-ovulation. Pituitary function was studied by radioimmunoassay determination of plasma growth hormone level after pyrogen stimulation, radioimmunoassay determination of follicle-stimulating and luteinizing hormone during clomiphene citrate stimulation, measurement of plasma cortisol level, and thyroid function studies. Results suggest normal pituitary responsiveness to provocative stimuli and support the concept that the control of ovulation is functionally independent of the control of lactation.
Wider JA, Marshall JR, Ross GT. Familial Galactorrhea in Three Sisters With Oligo-ovulation. JAMA. 1969;209(5):669-671. doi:10.1001/jama.1969.03160180015004