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August 11, 1969

A Peculiar Cutaneous Reaction to Repeated Injections of Insulin

Author Affiliations

From the Department of Medicine (Drs. Lipschutz and Kearse) and the Division of Dermatology (Maj Erickson and Dr. Wrigley). University of Colorado Medical Center, Denver.

JAMA. 1969;209(6):934-935. doi:10.1001/jama.1969.03160190056019

A bizarre skin lesion consisting of a collection of brown, hyperkeratotic papules appeared on the thighs of a 51-year-old diabetic man, after repeated insulin injections into the same area over a period of two or more years. The reason for the development of this type of lesion instead of the usual lipodystrophy that follows multiple insulin injections is obscure.