Four patients with chronic granulocytic leukemia (CGL) also have Gaucher cells present in their bone marrow aspirates. In one, a child with acute lymphoblastic leukemia, the association of leukemia and Gaucher cells seems coincidental since there was a family history of Gaucher's disease. In two patients with typical CGL and one with subacute granulocytic leukemia, a biochemical abnormality is postulated. Increased granulocyte turnover in CGL appears responsible for marked overproduction of glucocerebroside which is stored in the reticuloendothelial system.
Rosner F, Dosik H, Kaiser SS, Lee SL, Morrison AN. Gaucher Cells in Leukemia. JAMA. 1969;209(6):935–937. doi:10.1001/jama.1969.03160190057020