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August 11, 1969

Gaucher Cells in Leukemia

Author Affiliations

From the Division of Hematology, Department of Medicine, Maimonides Medical Center (Drs. Rosner, Dosik, Kaiser, and Lee), the Jewish Hospital of Brooklyn (Dr. Morrison), and the Acute Leukemia Cooperative Chemotherapy Group B, Brooklyn, NY.

JAMA. 1969;209(6):935-937. doi:10.1001/jama.1969.03160190057020

Four patients with chronic granulocytic leukemia (CGL) also have Gaucher cells present in their bone marrow aspirates. In one, a child with acute lymphoblastic leukemia, the association of leukemia and Gaucher cells seems coincidental since there was a family history of Gaucher's disease. In two patients with typical CGL and one with subacute granulocytic leukemia, a biochemical abnormality is postulated. Increased granulocyte turnover in CGL appears responsible for marked overproduction of glucocerebroside which is stored in the reticuloendothelial system.