August 25, 1969

Disseminated Herpes Simplex With Encephalitis in a NeonateTreatment With Idoxuridine

Author Affiliations

From the Department of Ophthalmology, University of Iowa College of Medicine, Iowa City.

JAMA. 1969;209(8):1219-1221. doi:10.1001/jama.1969.03160210051017

A premature baby had neonatal disseminated herpes simplex. Idoxuridine therapy was started when the infant was 12 days old and it was given intravenously for five days in a dose of 100 mg/kg/day. Clinical recurrence of the herpetic infection developed 20 days after the initial therapeutic course, and a second course of idoxuridine was successful in eradicating the virus.