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September 13, 1976

Prenatal Diagnosis of Neural Tube Defects

Author Affiliations

From the departments of animal research (Dr Macri and Mr Elligers), obstetrics and gynecology (Dr Weiss), and radiology (Drs Tillitt and Balsam), Nassau County Medical Center, East Meadow, NY.

JAMA. 1976;236(11):1251-1254. doi:10.1001/jama.1976.03270120027019

A prospective program for the prenatal detection of neural tube defects in a high-risk pregnancy group has been under way for one year. Twenty high-risk mothers have undergone a complete prenatal work-up, including sonography, amniocentesis, and amniotic fluid and maternal serum α-fetoprotein quantitation. Within this group, two cases were prospectively diagnosed and were later confirmed.

(JAMA 236:1251-1254, 1976)