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June 11, 1973

Medical News

JAMA. 1973;224(11):1473-1483. doi:10.1001/jama.1973.03220250003002

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Specific antibodies—next aid in cancer diagnosis, treatment?  The use of specific antibodies directed against tumor cells for both diagnosis and treatment of some cancers now seems within reach, according to researchers at Harvard Medical School.Diagnostically, such antibodies—which are made in another animal species—can be radioactively labeled and injected into the patient's body. Therapeutically, the antibodies, labeled or not, can be injected intraperitoneally.In the diagnostic area, Stanley E. Order, MD, associate professor of radiation therapy, and coworkers at the Joint Center for Radiation Therapy in Boston recently have been purifying and using antibody made in rabbits against two human antigens associated with Hodgkin disease. One antigen, called F (fast-migrating) antigen or proliferation antigen, occurs in Hodgkin tumors and other diseases where lymphocytes are reactive against abnormal products. The other, called S (slow-migrating) antigen or neoplastic antigen, occurs in Hodgkin disease and also has been found in a malignant lymphocytic