A 49-year-old man with an osteosclerotic lesion of a thoracic vertebra had peripheral neuropathy, lymphadenopathy, and elevated serum alkaline phosphatase and monoclonal immunoglobulin levels in the cerebrospinal fluid. These findings, not usually seen in "classical" myeloma, have been noted in different combinations in the osteosclerotic variety.
(JAMA 236:1872-1874, 1976)
Rodriguez AR, Lutcher CL, Coleman FW. Osteosclerotic Myeloma. JAMA. 1976;236(16):1872-1874. doi:10.1001/jama.1976.03270170038023