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October 18, 1976

Serum Levels of Immunoglobulin and Complement in Giant-Cell Arteritis

Author Affiliations

From the Department of Infectious Diseases, East Hospital, University of Göteborg (Drs Malmvall and Alestig); the Department of Medicine III, Sahlgren's Hospital, Göteborg, Sweden (Dr Bengtsson); and the Department of Medical Microbiology, University of Göteborg (Drs Kaijser and Nilsson).

JAMA. 1976;236(16):1876-1878. doi:10.1001/jama.1976.03270170042025

The levels of IgG, total complement, and complement factors C3 and C4 were elevated in serum from patients with giant-cell arteritis as compared to a control group of patients in the same range of age. No increase of the IgM concentration was found. The concentration of IgA was higher in men with giant-cell arteritis as compared to men in a control group. This increase of IgA was not seen in women. There were no statistically significant differences in any of the studied variables between those with a histologically verified arteritis on temporal biopsy specimens and those without.

(JAMA 236:1876-1878, 1976)