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April 30, 1973

Section 13.—Necrotizing Arteritis and Other Forms of Vasculitis

JAMA. 1973;224(Suppl_5):722-726. doi:10.1001/jama.1973.03220190062016

A group of clinical syndromes is considered here which are characterized by segmental inflammation of the blood vessels, chiefly of arteries of medium or small caliber, and by clinical manifestations which vary with the site and severity of arterial involvement. The syndromes are in general separable on the basis of clinical and histopathologic features and by the distribution of lesions in the vascular system. The findings in individual cases may vary considerably, however, and exact categorization may prove difficult, if not impossible, during life, because one may be unable to determine the full extent of the disease. Over the years a variety of names and classifications have been introduced, resulting in some confusion. Nevertheless an attempt at such separation is of considerable value, especially since there are appreciable differences in prognosis and appropriate therapy (tabulation below). The vascular changes that occur in rheumatoid arthritis,1 systemic lupus erythematosus, progressive systemic