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October 27, 1969

Classification of Primary HyperlipidemiaObservations on 214 Patients

Author Affiliations

From the Division of Cardiovascular Diseases, Henry Ford Hospital, Detroit. Dr. Schatz is now with the Department of Medicine, Wayne State University School of Medicine, Detroit.

JAMA. 1969;210(4):701-704. doi:10.1001/jama.1969.03160300041008

Classification of the hyperlipoproteinemias permits a rational approach to the diagnosis and management of these conditions. This study included 214 patients with primary hyperlipidemia. The Fredrickson-Lees criteria were used. There were no type 1 cases, 75 type 2, 12 type 3, 71 type 4, 12 type 5, and 44 unclassifiable. Abnormal responses to glucose tolerance tests occurred in 3 of 23 patients with type 2 and 52 of 54 patients with types 3, 4, and 5 disease. Most cases may be classified successfully if the patient's clinical history, fasting serum cholesterol and triglyceride levels, and serum lactescence are known; in this group, the omission of lipoprotein electrophoresis altered classification in no type 2, six type 3, and four type 4 patients.