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To the Editor.—
I am a psychiatrist practicing essentially clinical psychopharmacology and I have long been disturbed by the lack of data and studies with respect to the effects of the elevations of serum prolactin produced by antipsychotic agents.Like the treatment of hypertension, the treatment of psychosis generally involves long-term administration of agents that are well known and well demonstrated to raise serum prolactin levels. It would seem time that we begin to take a look at the incidence of carcinomas in patients who have been exposed to these agents for prolonged periods of time. I think it is very likely that when the data are compared it will be discovered that the elevation of prolactin with antipsychotic agents are at least as high if not higher than those found with reserpine, and these agents would probably give a much larger population to study.
Masco HL. Antipsychotic Agents and Serum Prolactin Levels. JAMA. 1976;236(19):2175. doi:10.1001/jama.1976.03270200015018