Pregnancy was observed 105 times in narcotic-addicted women in the Methadone Maintenance Treatment Program of the Beth Israel Medical Center. There was no maternal mortality. Complications of pregnancy and fetal wastage were unremarkable. One third of the infants were premature by weight. Management in labor was modified only by the addition of methadone hydrochloride treatment. No serious effects attributable to methadone were seen in the neonatal period, and followup revealed normal growth and development.
Blinick G, Jerez E, Wallach RC. Methadone Maintenance, Pregnancy, and Progeny. JAMA. 1973;225(5):477-479. doi:10.1001/jama.1973.03220320013004