For years the group of disorders generally referred to as the necrotizing angiitides have been a source of confusion to both pathologists and clinicians. The lesions can have many forms, produce a host of different symptoms, and can accompany a variety of apparently unrelated clinical conditions.
Since "periarteritis nodosa" was first described by Kussmaul and Maier in 1866,1 the meaning of the term has changed considerably. A subsequent proliferation of reports has broadened and somewhat obscured the original definition, so that today the term periarteritis nodosa, or "polyarteritis nodosa," is applied rather loosely by some as a histologic description to many necrotizing arterial lesions, while it is reserved by others for a clinical syndrome of which the arterial lesions are a feature. Perhaps the most widely used terminology currently applied to the angiitides is that proposed by Zeek in 1952,2 though there are many cases which cannot wholly
Hypertensive Pulmonary Arteritis. JAMA. 1969;210(6):1095-1096. doi:10.1001/jama.1969.03160320077022