The occurrence of metastatic bone disease is proved by needle bone biopsy in two patients with negative fluoride 18 bone scans and bone roentgenograms. Hypercalcemia suggested the possibility of metastatic disease.
Becker FO, Schwartz TB. Normal Fluoride 18 Bone Scans in Metastatic Bone Disease. JAMA. 1973;225(6):628-629. doi:10.1001/jama.1973.03220330040011