Two hundred two patients participated in a double-blind random crossover study of the effectiveness of human chorionic gonadotropin (HCG) vs placebo in a weight reduction program. Serial measurements were made of weight, skin-fold thickness, dropout rates, reasons for dropping out, and patient subjective response. There was no statistically significant difference between those receiving HCG vs placebo during any phase of this study (P>.1).
(JAMA 236:2495-2497, 1976)
Young RL, Fuchs RJ, Woltjen MJ. Chorionic Gonadotropin in Weight ControlA Double-Blind Crossover Study. JAMA. 1976;236(22):2495–2497. doi:10.1001/jama.1976.03270230017019