[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.130.145. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 3, 1977

Mannitol and Amphotericin B-Reply

Author Affiliations

University of Pittsburgh School of Medicine Pittsburgh

JAMA. 1977;237(1):27. doi:10.1001/jama.1977.03270280029016

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

In Reply.—  We would like to thank Dr Jotkowitz for his interest. The patient's weight was 70 kg. As stated in the article, 25 gm mannitol was added to 17.5 mg amphotericin B and both medications in solution were infused simultaneously. Specifically, amphotericin B powder was diluted with the manufacturer's supplied diluent to a concentration of 5 mg/ml. Then 3.5 ml of this amphotericin solution was added to 125 ml of a 20% mannitol solution, which was then diluted with 5% dextrose in water to 1,000 ml prior to infusion. The final amphotericin B concentration was 0.0175 mg/ml and the mannitol was a 2.5% solution.

×