This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
We would like to thank Dr Jotkowitz for his interest. The patient's weight was 70 kg. As stated in the article, 25 gm mannitol was added to 17.5 mg amphotericin B and both medications in solution were infused simultaneously. Specifically, amphotericin B powder was diluted with the manufacturer's supplied diluent to a concentration of 5 mg/ml. Then 3.5 ml of this amphotericin solution was added to 125 ml of a 20% mannitol solution, which was then diluted with 5% dextrose in water to 1,000 ml prior to infusion. The final amphotericin B concentration was 0.0175 mg/ml and the mannitol was a 2.5% solution.
Rosch JM, Pazin G, Fireman P. Mannitol and Amphotericin B-Reply. JAMA. 1977;237(1):27. doi:10.1001/jama.1977.03270280029016