[Skip to Content]
[Skip to Content Landing]
October 29, 1973

Antiarrhythmic Agents

Author Affiliations

Tufts University School of Medicine Boston

JAMA. 1973;226(5):571. doi:10.1001/jama.1973.03230050049030

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


In just 115 pages of text, Drs. Moss and Patton have carefully condensed the current understanding of the physiology, pharmacology, and practical therapeutics of managing cardiac rhythm disturbances. Section I (the first three chapters) covers electrophysiology, mechanisms producing arrhythmias, and pharmacodynamic principles. Section II devotes a chapter to each of ten antiarrhythmic agents, including such "household" items as quinidine, procainamide, propranolol, digitalis glycosides, lidocaine, diphenylhydantoin, isoproterenol, and atropine, plus the less familiar bretylium. These are individually described on the basis of chemistry, pharmacology, and electrophysiology, followed by therapeutic uses and adverse reactions. Each discussion is keyed to the principles and illustrations that had been presented in section I.

Chapters 14 and 15 form section III. They cover, respectively, a comparison of the ten antiarrhythmic agents and the management of refractory dysrhythmias. Excellent comparative tables are included, and there is one showing relative costs of medications. The appendix lists their proprietary