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November 5, 1973

Noninterference of Oxazepam, Tranxene-4306CB, and Nordiazepam With Serum Glucose Determinations

Author Affiliations

Abbott Laboratories North Chicago, Ill

JAMA. 1973;226(6):675. doi:10.1001/jama.1973.03230060051028

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To the Editor.—  A letter in The Journal (215:1986, 1971) by Zileli et al described an attempted suicide by oxazepam overdose, resulting in simulated nonketoacidotic diabetic coma. The authors attributed an apparent blood glucose level of 1,680 mg/100 ml to interference of circulating oxazepam with glucose determinations. The specific analytical procedure used to determine the serum was not mentioned. The authors mixed one tablet of oxazepam (10 mg) with 2 ml of distilled water and subjected the clear supernatant to glucose determinations by the Somogyi method and the glucose oxidase reaction. Glucose concentrations of 750 and 590 mg/100 ml were found, respectively.To corroborate these data, a series of samples were prepared to contain 5, 10, and 20μg/ml of nordiazepam, chlorazepate dipotassium (Tranxene), and oxazepam, as well as the contents of one oxazepam (Serax) capsule dissolved in 5 ml of serum. These ten samples, as well as a blank from