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December 3, 1973

The Adrenal Cortex in Practical Medicine

Author Affiliations

Mt. Sinai School of Medicine New York

JAMA. 1973;226(10):1239. doi:10.1001/jama.1973.03230100057033

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This short book presents a very brief review of the biochemistry and physiology of the adrenal cortex and moderately detailed discussions of the clinical disorders of the gland. In an attempt to be brief, the material dealing with steroid synthesis and metabolism and measurement of adrenocortical function has been presented superficially. In particular, the effects of physiological and excess amounts of cortisol on intermediary metabolism are inadequately considred. The discussion of the plasma 17-hydroxycorticosteroid determination mentions that 11-deoxycortisol compounds give the same reaction but it does not give an explanation. The importance of pregnanetriol in the diagnosis of congenital adrenal hyperplasia is pointed out, but it is not stated that this steroid is a metabolite of 17-hydroxyprogesterone.

The chapters on adrenocortical diseases are more complete; however, some opinions expressed by the author would not be accepted by many endocrinologists. For example, in the chapter on Cushing syndrome it is stated