A 67-year-old white man developed Coombs test-positive hemolytic anemia secondary to levodopa therapy for Parkinson disease. The initial episode of anemia occurred after 11 months and 660 gm of drug exposure. A warm autoantibody directed against the Rh locus was found in the patient's serum and on his erythrocytes. On discontinuance of levodopa therapy, the autoimmune hemolytic anemia abated.
Territo MC, Peters RW, Tanaka KR. Autoimmune Hemolytic Anemia Due to Levodopa Therapy. JAMA. 1973;226(11):1347-1348. doi:10.1001/jama.1973.03230110039008