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December 24, 1973

Thirst Control

Author Affiliations

Brooke Army Medical Center Fort Sam Houston, Tex

JAMA. 1973;226(13):1570. doi:10.1001/jama.1973.03230130058030

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To the Editor.—  These comments are certainly appropriate to our current understanding of certain pharmacological agents used as antirenin agents, the pathophysiology involving the anemia of renal failure, and Vitamin-D metabolism.Our patient underwent bilateral nephrectomy before a trial of propanalol therapy, because propanalol was not widely known to be an effective antirenin agent at the time. Since the publication of this case report, we have had one other case of excessive thirst.

Report of a Case.—  The patient was a 66-year-old white man with chronic renal failure secondary to chronic glomerulonephritis. His excessive thirst resulted in weight gains of 4 to 5 kg between dialyses. Peripheral renin concentrations on several occasions ranged from 35 to 74 ng/ml/hr. The infusion of two liters of normal saline over two hours resulted in no real change in renin concentrations with a preinfusion value of 28.7 ng/ml/hr and a postinfusion value of 20.0