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December 24, 1973

Immunotherapy for Melanoma

JAMA. 1973;226(13):1571. doi:10.1001/jama.1973.03230130059034

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To the Editor.—  In the editorial "Immunotherapy for-Melanoma" (225:1242, 1973), there is the statement,Particularly gratifying are the results in leukoplakias, keratoses, and squamous and basal cell carcinomas, which have been frequently eradicated for five years or longer without recurrence.I think it should be pointed out that leukoplakias, keratoses, and squamous and basal cell carcinomas can be treated easily with available surgical techniques or radiation, without immunotherapy. The latter is more cumbersome and less certain to insure eradication. Fluororacil in the treatment of some of these lesions works by its cytotoxic action in premalignant lesions and poorly in malignant lesions, such as squamous cell carcinomas and basal cell carcinomas.It is in the treatment of melanoma that immunotherapy holds out the greatest hope and perhaps in mycosis fungoides, lymphomas, Kaposi sarcoma, and reticulum cell sarcoma.The basal cell carcinoma and squamous cell carcinoma have a cure rate of better