A girl, aged 14, had an extensive normolipemic xanthomatous eruption develop in one leg and foot, soon after the onset of lymphedema in the same limb. When the edema was reduced by treatment, the xanthomatous eruption greatly improved. It was speculated whether mechanical stretching of the skin might have been a factor contributing to the localized development of xanthomatosis in a xanthoma-prone individual.
Woolling KR, Jenkins RE, Dolan PA, Evans PV. Localized Xanthomas in Lymphedema Praecox. JAMA. 1970;211(8):1372-1374. doi:10.1001/jama.1970.03170080060017