A hydrocortisone preparation containing methylparaben and propylparaben provoked bronchospasm and pruritis when given intravenously to an asthmatic patient, whereas another hydrocortisone preparation without paraben preservative did not. Direct and passive transfer (Prausnitz-Küstner) skin tests for immediate hypersensitivity to parabens were positive. Parabens, frequently employed as bacteriostatic agents, are capable of producing immunologically mediated, immediate systemic hypersensitivity reactions.
(JAMA 237:1594-1595, 1977)
Nagel JE, Fuscaldo JT, Fireman P. Paraben Allergy. JAMA. 1977;237(15):1594-1595. doi:10.1001/jama.1977.03270420062018