[Skip to Content]
[Skip to Content Landing]
January 28, 1974

Radioimmunoassay for Calcitonin in Medullary Thyroid Carcinoma

Author Affiliations

From the University of California San Diego School of Medicine and the Endocrine Section, Veterans Hospital, La Jolla, Calif.

JAMA. 1974;227(4):403-406. doi:10.1001/jama.1974.03230170019004

Basal levels of calcitonin were abnormally elevated in 26 of 33 patients with medullary carcinoma of the thyroid. In three patients with nondiagnostic basal concentrations, calcitonin increased to diagnostic levels after calcium infusion; only a ten-minute infusion was needed in one patient. In some patients, the ratio of calcitonin in veins draining the tumor to that in peripheral veins ranged from 4.3 to 57.0. These studies demonstrate the value of the calcitonin immunoassay in the diagnosis and localization of medullary thyroid carcinoma.