A passive hemagglutination method for circulating autoantibody to purified human skeletal muscle myoglobin has been developed. This antibody was detected in the sera of 22 of 31 patients with polymyositis. The incidence and the antibody titers were significantly higher than in other myopathies such as myasthenia gravis (P <.02), Duchenne-type muscular dystrophy (P <.001), and other conditions (P <.001). This new antibody test is useful in diagnosing polymyositis.
(JAMA 237:1842-1844, 1977)
Nishikai M, Homma M. Circulating Autoantibody Against Human Myoglobin in Polymyositis. JAMA. 1977;237(17):1842–1844. doi:10.1001/jama.1977.03270440032016