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Article
April 25, 1977

Circulating Autoantibody Against Human Myoglobin in Polymyositis

Author Affiliations

From the Department of Internal Medicine, School of Medicine, Keio University, Tokyo. Dr Nishikai is now with the Department of Medicine, State University of New York at Buffalo School of Medicine and Veterans Administration Hospital, Buffalo.

JAMA. 1977;237(17):1842-1844. doi:10.1001/jama.1977.03270440032016
Abstract

A passive hemagglutination method for circulating autoantibody to purified human skeletal muscle myoglobin has been developed. This antibody was detected in the sera of 22 of 31 patients with polymyositis. The incidence and the antibody titers were significantly higher than in other myopathies such as myasthenia gravis (P <.02), Duchenne-type muscular dystrophy (P <.001), and other conditions (P <.001). This new antibody test is useful in diagnosing polymyositis.

(JAMA 237:1842-1844, 1977)

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