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March 16, 1970

Oxygen Releasing Factor in Hyperthyroidism

Author Affiliations

From the departments of pediatrics (Drs. W. Miller and Oski), physiology, Graduate Division (Dr. Delivoria-Papadopoulos), and surgery (Dr. L. Miller), University of Pennsylvania School of Medicine; Children's Hospital of Philadelphia (Dr. W. Miller); and the Hospital of the University of Pennsylvania (Drs. Oski and L. Miller), Philadelphia. Dr. W. Miller is now with the Department of Pediatrics, University of Texas Southwestern Medical School, Dallas.

JAMA. 1970;211(11):1824-1826. doi:10.1001/jama.1970.03170110030005

Two subjects with hyperthyroidism had increased release of oxygen from blood and elevated concentrations of red blood cell 2, 3-diphosphoglycerate. This organic phosphate can be established as the primary regulator of oxygen release from hemoglobin in this and in other clinical conditions with imbalance of oxygen supply and demand.