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March 16, 1970

Comparison of Acetylmethadol and Methadone in the Treatment of Long-Term Heroin UsersA Pilot Study

Author Affiliations

From the departments of psychiatry, University of Chicago and the Illinois Department of Mental Health, Chicago (Drs. Jaffe and Schuster, and Mrs. Smith) and the Department of Psychiatry, University of Oregon, Portland (Dr. Blachley).

JAMA. 1970;211(11):1834-1836. doi:10.1001/jama.1970.03170110040008

In a double-blind controlled study, d1-α-acetylmethadol hydrochloride a synthetic congener of methadone hydrochloride with a 72- to 96-hour duration of action was compared to methadone in the treatment of long-term compulsive heroin users. The subjects were ambulatory patients whose conditions were already stabilized with oral administration of methadone. Over a five-week period of observation there were no differences in social adjustment between those patients whose conditions were maintained with a daily methadone regimen and those given d1-α-acetylmethadol three times a week.