February 11, 1974

Spurious Thrombocytopenia

Author Affiliations

From the Division of Clinical Pathology, Department of Pathology (Dr. Kjeldsberg), and Division of Hematology, Department of Medicine (Dr. Hershgold), University of Utah Medical Center, Salt Lake City.

JAMA. 1974;227(6):628-630. doi:10.1001/jama.1974.03230190020005

Extensive clinical investigation is usually demanded by the report of thrombocytopenia. Therefore, it is important to be aware that, even with automated equipment, low platelet counts may be erroneous due to causes such as giant platelets, platelet agglutinins, and platelet satellitism. Each of these may lead to a spurious diagnosis of thrombocytopenia because of in vitro artifact.