Extensive clinical investigation is usually demanded by the report of thrombocytopenia. Therefore, it is important to be aware that, even with automated equipment, low platelet counts may be erroneous due to causes such as giant platelets, platelet agglutinins, and platelet satellitism. Each of these may lead to a spurious diagnosis of thrombocytopenia because of in vitro artifact.
Kjeldsberg CR, Hershgold EJ. Spurious Thrombocytopenia. JAMA. 1974;227(6):628-630. doi:10.1001/jama.1974.03230190020005