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April 6, 1970

Treatment of Sporotrichosis

JAMA. 1970;212(1):160. doi:10.1001/jama.1970.03170140116039

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To the Editor.—  Dr. Hornick's comments are well taken. He is perfectly correct in reminding the readers that there is no good evidence that griseofulvin is effective in the treatment of sporotrichosis. Our intention was not to suggest the drug as a mode of therapy for sporotrichosis, but rather to include it in a list of agents that have been used by other physicians for cutaneous sporotrichosis. There is no justification for using this drug in either cutaneous or disseminated sporotrichosis. The drug of choice has been and remains amphotericin-B. Potassium iodide is often used, effectively, in the therapy of cutaneous sporotrichosis and has been advocated by some as a justified medication in pulmonary sporotrichosis. We feel, however, that in any manifestation more severe than the cutaneous form, amphotericin should still be the primary drug.