Shortly after initiating therapy with allopurinol, eosinophilia developed in a 72-year-old man along with toxic epidermal necrolysis and renal failure followed by sepsis, pneumonia, and death. Pathological findings revealed degeneration of the epidermis with bullae at the dermalepidermal junction and within the epidermis and also intense immunoglobulin deposits along the glomerular basement membrane.
Kantor GL. Toxic Epidermal Necrolysis, Azotemia, and Death After Allopurinol Therapy. JAMA. 1970;212(3):478-479. doi:10.1001/jama.1970.03170160066019