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To the Editor.—
During the past three months I have observed four young adults with an illness characterized by abdominal pain, myalgia, arthralgia, malaise, and lethargy, associated with a marked peripheral blood eosinophilia and a slight to moderate atypical lymphomonocytosis. Three of the four were hospitalized with acute abdominal distress. Symptoms and signs of a broad spectrum of gastrointestinal disorders and peritoneal inflammation were present intermittently for periods of two to eight weeks. One patient was examined by a gynecologist, and a diagnosis of salpingitis was offered. Extensive gastrointestinal, endoscopic, and roentgenographic examinations were negative, as were repeated studies for autoimmune, parasitic, fungal, and viral disorders. One patient had slight splenomegaly. Adenopathy was minimal to absent in all cases, and hepatomegaly was not observed. The degree of eosinophilia in the three sickest patients ranged from 10% to 28% during intervals of two to eight weeks. Complete recovery and concomitant resolution
Lustgarten BP. Eosinophilia. JAMA. 1974;228(4):461. doi:10.1001/jama.1974.03230290017008