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May 11, 1970

Delayed Reaction to Aqueous Hyposensitization Material

Author Affiliations

University of Michigan Medical Center Ann Arbor

JAMA. 1970;212(6):1069. doi:10.1001/jama.1970.03170190083022

To the Editor.—  Delayed local reaction to hyposensitization emulsion extracts have been a major drawback in their use.1 However, delayed local reactions rarely occur with aqueous hyposensitization extracts.2,3 We report a case of what seems to be a delayed local reaction to aqueous hyposensitization extract.

Report of a Case.—  A 17-year-old Negro girl showed "lumps on the arm" starting in September 1967. Three months later, the lumps began to drain serous watery material. The patient had developed seasonal asthma (June to September) at 11 years of age. Thereafter, she received epinephrine in aqueous or oily suspension in the deltoid area. The last epinephrine in oil injection was received in August of 1966. Skin tests revealed positive reactions to house dust, trees, grass and weed pollens, and mold extracts. Subcutaneous injections of aqueous preparations of these were administered from Aug 18, 1966 to Sept 14, 1967. The maintenance dose