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May 11, 1970

Principles of General Neurology: An Introduction to the Basic Principles of Medical and Surgical Neurology

Author Affiliations

Washington University St. Louis

JAMA. 1970;212(6):1071. doi:10.1001/jama.1970.03170190085027

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Geared to neither beginner nor expert, this review of basic neurophysiology and neurochemistry addresses the silent majority of clinicians concerned with neurological function but unable to devote a life-time to its study. The author, steering clear of any direct comments on diagnosis and treatment, examines principles of neuronal metabolism, synaptic transmission, electroencephalography, drug action, cerebral blood flow and metabolism, and cerebral spinal fluid (CSF) production. Brain changes during learning are not discussed, nor are functions of various brain subsystems such as cerebellum or limbic system. References to the original literature are not included within the text but an exhaustive list of articles for further reading follows each group of chapters. A complete index allows ready reference to the text material.

Though the printing date is 1969, the book reads as if it were written years earlier. For example, the bibliography covering the rapidly changing field of synaptic transmission contains no