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July 18, 1977

Purified Duck Embryo Rabies VaccineAn Accelerated Schedule for Preexposure Immunization Against Rabies

Author Affiliations

From the Departments of Preventive Medicine and Medicine, University of Illinois College of Medicine, Chicago (Drs Nelson and Batt), the Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand (Drs Vithayasai, MakornKawKayoon, and Panas-Amporn), and the Eli Lilly Research Institute, Indianapolis (Dr Anderson).

JAMA. 1977;238(3):218-220. doi:10.1001/jama.1977.03280030026014

Seroconversion and adverse reaction rates were studied in 92 persons given four or five doses in a two-week period of duck embryo rabies vaccine (DEV) or duck embryo rabies vaccine purified by ultracentrifugation (P-DEV). Mouse-neutralizing antibodies developed in 78 of 92 (84.8%) persons in these accelerated schedules. There were no significant differences in the frequency of antibody conversion or in geometric mean titers of antibody between persons given either vaccine. However, local and systemic adverse reactions were substantially less common with P-DEV. These data suggest that four or five doses of DEV or P-DEV given in a two-week course can be used for preexposure prophylaxis in situations where the more drawn-out regimens would result in continuation of a high-risk of rabies exposure. The antibody response of persons given this more accelerated regimen must be determined.

(JAMA 238:218-220, 1977)