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May 20, 1974


Author Affiliations

Wayne State University School of Medicine Detroit

JAMA. 1974;228(8):1040. doi:10.1001/jama.1974.03230330070037

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Sir.—  In regard to the review of Sickle Cell Hemoglobin: Molecule to Man (227:805-806, 1974), let me take issue with Dr. Kraus's statements. He regards the text as "lucid, but rather one-sided." He has failed to recognize that the last five chapters are extensions, inferences, deductions, and clinical applications made from the Murayama hypothesis for the molecular mechanisms of sickling as discussed in the initial three chapters. I know of no other disease where such a continuous, logical linkage of concepts exists between theoretical and experimental molecular information on the one hand and analytically derived diagnostic and therapeutic gains on the other. Surely, this unique medical aspect of the book deserves at least passing acknowledgment. The book apparently appeared "one-sided" to Dr. Kraus because it is not a review of the sickle cell literature, a prodigious project; rather, the authors intended only to show in what ways the Murayama hypothesis could be used to make clinical gains.