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I am grateful to Drs Kalisher and Greenes for their conscientious reading of my paper and for their important comments. They considered the article as a large statistically defined study, while it was meant to be, as expressed, "suggesting another group at higher risk... for cancer of the breast" on the basis of a clinical observation. I am not alone in sensing the fear of inducing cancer of the breast by radiation, and this clinical observation on acne radiation appeared to warrant publication because of the possibility that such radiation contributed to the cause of cancer of the breast and because the records of such patients would provide a pool of data for study.In respect to the cogent questions concerning details of the radiation treatment for acne, I must note that I have exact data on the characteristics of radiation received in only one of the 16
Simon N. Radiation and Breast Cancer-Reply. JAMA. 1977;238(7):580. doi:10.1001/jama.1977.03280070019007