[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
June 29, 1970

Medical News

JAMA. 1970;212(13):2201-2214. doi:10.1001/jama.1970.03170260009003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Experts debate safety, uses of oral antidiabetic drugs  The question of the safety of sulfonylurea antidiabetic agents remains unresolved after heated discussion at the recent meeting of the American Diabetes Association (ADA) in St. Louis.Thaddeus E. Prout, MD, reported that diabetic patients treated with tolbutamide had a higher incidence of deaths due to cardiovascular complications than others treated with diet alone or insulin. Other physicians challenged his conclusion and in the end the ADA—at the first press conference in its history—issued a statement composed by an ad hoc scientific committee and read by Robert C. Hardin, MD, the ADA president for 1969-1970.The statement concluded that "At this point, the evidence presented does not appear to warrant abandoning presently accepted methods of the treatment of diabetes—diet, diet with oral agents, or diet with insulin as indicated."Dr. Prout, associate professor of medicine at Johns Hopkins University School of