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June 29, 1970

Leiomyosarcoma of Kidney

JAMA. 1970;212(13):2266-2267. doi:10.1001/jama.1970.03170260062023

To the Editor.—  In an exhaustive review, only 34 cases of leiomyosarcoma of the kidney could be found.Leiomyosarcoma is a malignant tumor consisting of elements of smooth muscle fibers. Crosbie and Piudoertjou1 recognized the rarity of such neoplasms generally occurring in the uterus, occasionally in the ovary, gastrointestinal tract, bladder, breast, retroperitoneal tissue, and prostate; and extremely rarely in the kidney. They postulated that the smooth muscle fibers present in the renal capsule, renal pelvis, calyces, or blood vessel wall, undergo malignant transformation, giving rise to the leiomyosarcoma. Smith2 reported one case of leiomyosarcoma of the kidney in 40 cases of tumor of the upper part of the urinary tract. In a review of 35 renal sarcomata removed surgically at the Mayo Clinic from 1904 to 1940, Weisel et al3 found only three cases of leiomyosarcoma possibly originating from the smooth muscle elements of the renal