The usefulness of isoxsuprine hyldochloride for the treatment of intermittent claudication was studied in 20 patients with arteriosclerosis obliterans. The study consisted of two four-week periods during which the patient was treated with both drug and placebo, the order of which was randomly assigned. The pattern of the postexercise hyperemic response was measured by the ankle systolic blood pressure response to exercise. A comparison of the drug and placebo treatment periods indicated that isoxsuprine did not improve the hyperemic response to exercise. On the basis of these data, it was not possible to demonstrate that isoxsuprine was useful in the treatment of intermittent claudication.
Strandness DE. Ineffectiveness of Isoxsuprine on Intermittent Claudication. JAMA. 1970;213(1):86–88. doi:10.1001/jama.1970.03170270028005